semaglutide and hormone therapy Therapy: What Perimenopausal Patients Should Know Is Semaglutide the Same as

Karczewski, K

### How Each Drug Performs at Key Milestones | Milestone | Orforglipron (36 mg) | Oral Semaglutide (50 mg) | Tirzepatide (15 mg) | |-----------|---------------------|-------------------------|---------------------| | **4 weeks** | ~2-3% | ~2-3% | ~3-4% | | **12 weeks** | ~6-8% | ~6-7% | ~8-10% | | **24 weeks** | ~10-12% | ~10-11% | ~14-16% | | **36 weeks** | ~14-15% | ~12-13% | ~17-19% | | **68-72 weeks** | ~15%+ (projected) | ~15.1% | ~20-22.5% | For detailed semaglutide weight loss trajectories, see our [semaglutide weight loss results timeline](/guides/semaglutide-weight-loss-results-timeline-what-to-expect)

Schauer PR, Bhatt DL, Kirwan JP, et al

Self-starting supplements without guidance increases risk

This timing may enhance fat oxidation during exercise by ensuring peak metabolic activation coincides with physical activity